The Online Collaborative Research Environment (OnCore) is a comprehensive web-based clinical trial management system (CTMS). OnCore offers investigators and research coordinators a centralized application to manage the complete life cycle of a study, from start-up and pre-award activities to closure. Key features of OnCore include protocol management, subject management, financial management, biospecimen management, patient registries, safety monitoring, and reporting. OnCore is a product of Advarra, based in Madison, WI.