The Proteomics Core provides consultation for experiment design in proteomic studies, state-of-the-art mass spectrometers, and advanced bioinformatic tools to the entire OUHSC research community and external researchers. Our proteomic solutions can be used to study a wide range of biomedical questions from untargeted biomarker discovery, signaling pathway analysis, interactome analysis and drug target analysis to targeted quantitation of proteins.
Services Offered
- Untargeted proteomics (DDA/DIA, label-free/TMT-labelled)
- Protein analysis for gel spots and immuno-precipitation (IP) samples
- Targeted proteomics
- Post-translational modification (PTM) analysis by electron transfer dissociation (ETD)
- Bioinformatic analysis
Instrumentations
- Thermo Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer with ETD
- Thermo Fisher Scientific TSQ Quantis Triple Quadrupole Mass Spectrometer
- SCIEX 7500+ Triple Quadrupole Mass Spectrometer
- Waters Xevo Multi-reflecting time-of-flight (MRT) Mass Spectrometer with Desorption Electrospray Ionization (DESI) XS
- Bruker timsTOF flleX Mass Spectrometer with Matrix Assisted Laser Desorption/Ionization (MALDI)
Software
- Proteome Discoverer
- MaxQuant
- FragPipe (MS Fragger search engine)