Mass Spectrometry & HPLC

Mass Spectrometry and/ or HPLC

Some compounds do not need any HPLC separation. This is particularly the case for small molecules from chemical synthesis where the final product mass or purity needs to be checked. This is done using our Waters Synapt G2S by direct injection. Buffer exchange might need to be performed so that the compound is in a proper volatile mass spec compatible buffer. 

Alternatively, the MALDI-TOF can be used. This can be a good solution if you have multiple samples to screen that are quite pure or if the results are needed quickly since the queue is usually shorter for the MALDI.


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